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dc.contributor.authorBobillo, María Cecilia
dc.contributor.authorBallantyne, Kaye N.
dc.contributor.authorArwin, Ralf
dc.contributor.authorAboukhalid, Rachid
dc.contributor.authorAchakzai, Niaz M.
dc.contributor.authorAnjos, Maria J.
dc.contributor.authorAyub, Qasim
dc.contributor.authorBalaªic, Joªe
dc.contributor.authorBallantyne, Jack
dc.contributor.authorBallard, David J.
dc.contributor.authorBerger, Burkhard
dc.contributor.authorBouabdellah, Mehdi
dc.contributor.authorBurri, Helen
dc.contributor.authorCapal, Tomas
dc.contributor.authorCaratti, Stefano
dc.contributor.authorCárdenas, Jorge
dc.contributor.authorCartault, François
dc.date.accessioned2020-12-05T15:06:15Z
dc.date.available2020-12-05T15:06:15Z
dc.date.issued2014-08
dc.identifier.urihttps://repo.unlpam.edu.ar/handle/unlpam/6853
dc.descriptionEl texto completo de este documento se accede desde computadoras de la UNLPam.
dc.description.abstractRelevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836–0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father–son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.
dc.format.extentp. 1021-1032
dc.format.mediumapplication/pdf
dc.language.isoeng
dc.publisherWiley Periodicals
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceHuman Mutation. 2014; vol.35 no.8
dc.titleToward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
dc.typeartículo
dc.unlpam.subtypeArtículos
dc.unlpam.doihttp://dx.doi.org/10.1002/humu.22599
dc.unlpam.instituciondeorigenFacultad de Ciencias Económicas y Jurídicas
dc.unlpam.eissne1098-1004
dc.unlpam.accessopenAccess
dc.unlpam.versionpublisherVersion
dc.unlpam.filiacionBobillo, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.unlpam.filiacionBobillo, María Cecilia. Universidad Nacional de La Pampa; Argentina.
dc.unlpam.filiacionBallantyne, Kaye N.. University Medical Centre Rotterdam; Netherlands.
dc.unlpam.filiacionArwin, Ralf. University Medical Centre Rotterdam; Netherlands.
dc.unlpam.filiacionAboukhalid, Rachid. Mohammed V Agdal University; Morocco.
dc.unlpam.filiacionAchakzai, Niaz M.. University of the Punjab; Pakistan.
dc.unlpam.filiacionAnjos, Maria J.. National Institute of Legal Medicine and Forensic Sciences; Portugal.
dc.unlpam.filiacionAyub, Qasim. Wellcome Trust Genome Campus; UK.
dc.unlpam.filiacionBalaªic, Joªe. University of Ljubljana; Slovenia.
dc.unlpam.filiacionBallantyne, Jack. University of Central Florida; Estados Unidos.
dc.unlpam.filiacionBallard, David J.. Department of Forensic and Analytical Science; UK.
dc.unlpam.filiacionBerger, Burkhard. Innsbruck Medical University; Austria.
dc.unlpam.filiacionBouabdellah, Mehdi. Mohammed V Agdal University; Morocco.
dc.unlpam.filiacionBurri, Helen. University of Zurich,; Switzerland.
dc.unlpam.filiacionCapal, Tomas. Institute of Criminalistics Prague; Czech Republic.
dc.unlpam.filiacionCaratti, Stefano. University of Turin; Italy.
dc.unlpam.filiacionCárdenas, Jorge. University of Santiago de Compostela; Spain.
dc.unlpam.filiacionCartault, François. Site Centre Hospitalier Felix Guyon; Francia.


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Attribution 4.0 International (CC BY 4.0)
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