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Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
dc.contributor.author | Bobillo, María Cecilia | |
dc.contributor.author | Ballantyne, Kaye N. | |
dc.contributor.author | Arwin, Ralf | |
dc.contributor.author | Aboukhalid, Rachid | |
dc.contributor.author | Achakzai, Niaz M. | |
dc.contributor.author | Anjos, Maria J. | |
dc.contributor.author | Ayub, Qasim | |
dc.contributor.author | Balaªic, Joªe | |
dc.contributor.author | Ballantyne, Jack | |
dc.contributor.author | Ballard, David J. | |
dc.contributor.author | Berger, Burkhard | |
dc.contributor.author | Bouabdellah, Mehdi | |
dc.contributor.author | Burri, Helen | |
dc.contributor.author | Capal, Tomas | |
dc.contributor.author | Caratti, Stefano | |
dc.contributor.author | Cárdenas, Jorge | |
dc.contributor.author | Cartault, François | |
dc.date.accessioned | 2020-12-05T15:06:15Z | |
dc.date.available | 2020-12-05T15:06:15Z | |
dc.date.issued | 2014-08 | |
dc.identifier.uri | https://repo.unlpam.edu.ar/handle/unlpam/6853 | |
dc.description | El texto completo de este documento se accede desde computadoras de la UNLPam. | |
dc.description.abstract | Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836–0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father–son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database. | |
dc.format.extent | p. 1021-1032 | |
dc.format.medium | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Wiley Periodicals | |
dc.rights | Attribution 4.0 International (CC BY 4.0) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Human Mutation. 2014; vol.35 no.8 | |
dc.title | Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats | |
dc.type | artículo | |
dc.unlpam.subtype | Artículos | |
dc.unlpam.doi | http://dx.doi.org/10.1002/humu.22599 | |
dc.unlpam.instituciondeorigen | Facultad de Ciencias Económicas y Jurídicas | |
dc.unlpam.eissn | e1098-1004 | |
dc.unlpam.access | openAccess | |
dc.unlpam.version | publisherVersion | |
dc.unlpam.filiacion | Bobillo, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. | |
dc.unlpam.filiacion | Bobillo, María Cecilia. Universidad Nacional de La Pampa; Argentina. | |
dc.unlpam.filiacion | Ballantyne, Kaye N.. University Medical Centre Rotterdam; Netherlands. | |
dc.unlpam.filiacion | Arwin, Ralf. University Medical Centre Rotterdam; Netherlands. | |
dc.unlpam.filiacion | Aboukhalid, Rachid. Mohammed V Agdal University; Morocco. | |
dc.unlpam.filiacion | Achakzai, Niaz M.. University of the Punjab; Pakistan. | |
dc.unlpam.filiacion | Anjos, Maria J.. National Institute of Legal Medicine and Forensic Sciences; Portugal. | |
dc.unlpam.filiacion | Ayub, Qasim. Wellcome Trust Genome Campus; UK. | |
dc.unlpam.filiacion | Balaªic, Joªe. University of Ljubljana; Slovenia. | |
dc.unlpam.filiacion | Ballantyne, Jack. University of Central Florida; Estados Unidos. | |
dc.unlpam.filiacion | Ballard, David J.. Department of Forensic and Analytical Science; UK. | |
dc.unlpam.filiacion | Berger, Burkhard. Innsbruck Medical University; Austria. | |
dc.unlpam.filiacion | Bouabdellah, Mehdi. Mohammed V Agdal University; Morocco. | |
dc.unlpam.filiacion | Burri, Helen. University of Zurich,; Switzerland. | |
dc.unlpam.filiacion | Capal, Tomas. Institute of Criminalistics Prague; Czech Republic. | |
dc.unlpam.filiacion | Caratti, Stefano. University of Turin; Italy. | |
dc.unlpam.filiacion | Cárdenas, Jorge. University of Santiago de Compostela; Spain. | |
dc.unlpam.filiacion | Cartault, François. Site Centre Hospitalier Felix Guyon; Francia. |
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